TY  -  JOUR
AU  -  Rebelos, Eleni
AU  -  Cipriano, Alessandro
AU  -  Maffei, Alessio
AU  -  Diricatti, Gaetano
AU  -  Santini, Massimo
T1  -  Marked increase in procalcitonin concentrations 
after hydrochlorothiazide-induced pulmonary edema
PY  -  2017
Y1  -  2017-04-01
DO  -  10.1701/2681.27456
JO  -  Recenti Progressi in Medicina
JA  -  Recenti Prog Med
VL  -  108
IS  -  4
SP  -  197
EP  -  199
PB  -  Il Pensiero Scientifico Editore
SN  -  2038-1840
Y2  -  2026/05/17
UR  -  http://dx.doi.org/10.1701/2681.27456
N2  -  Summary. Introduction. In the Medline database there are approximately 60 cases reporting toxic pulmonary edema, a life-threatening event, induced after consumption of hydrochlorothiazide, one of the most common antihypertensive drugs. Moreover, increased procalcitonin concentrations have been reported after cardiogenic pulmonary edema. We report the rare case of a hydrochlorothiazide-induced pulmonary edema, which was followed by a marked increase of the procalcitonin concentrations. Clinical case. A middle-aged woman was admitted to the Emergency Department for severe dyspnea and chills. Such symptoms began 30 minutes after consumption of hydrochlorothiazide. Her physical examination and chest-X-ray were compatible with pulmonary edema, however her brain natriuretic peptide levels and echocardiogram were almost normal. Interestingly she had extremely elevated procalcitonin concentrations with normal white blood cells count and C-reactive protein levels only mildly increased. We hypothesized toxic pulmonary edema and started treatment with non-invasive mechanical ventilation, with the patient presenting rapid clinical improvement. Conclusions. Even if extremely rare, hydrochlorothiazide may induce pulmonary edema; significant increase of procalcitonin concentrations may occur in this condition and perhaps in other cases of toxic pulmonary edema. Practitioners should be aware of this condition in order to spare expensive and useless, in this case, investigations such as blood cultures and treatments (antibiotics) if other signs of infection are absent.
ER  -