TY  -  JOUR
AU  -  Varchetta, Veronica
AU  -  Campanella, Carla
AU  -  Rossi, Michele
AU  -  Verzaro, Roberto
AU  -  Vitale, Marco
AU  -  Soda, Giuseppe
AU  -  Mancuso, Andrea
T1  -  Identification of anaplastic lymphoma kinase fusion
in clear cell renal carcinoma (ALK-tRCC):
a precision oncology medicine case report
PY  -  2021
Y1  -  2021-01-01
DO  -  10.1701/3525.35133
JO  -  Recenti Progressi in Medicina
JA  -  Recenti Prog Med
VL  -  112
IS  -  1
SP  -  14
EP  -  15
PB  -  Il Pensiero Scientifico Editore
SN  -  2038-1840
Y2  -  2026/04/21
UR  -  http://dx.doi.org/10.1701/3525.35133
N2  -  Summary. Background. Translocation-associated renal cell carcinoma involving ALK (ALK-tRCC) is a rare subtype of adult renal cell carcinoma (RCC) reported in recent years. Case presentation. A new Italian case of ALK-tRCC was reported. The patient was a female 44-year-old with a metastatic and pretreated RCC. The tumor showed a rearrangement of ALK gene in tumor cells detected by targeted next-generation sequencing panel. The patient received oral alectinib therapy and achieved a partial response. Conclusions. ALK-tRCC is a rare subtype of adult RCC. Its diagnosis is very difficult because the genomic alteration spectrum is very wide. We suggested that metastatic RCCs should be screened for uncommon genomic alterations expecially in good performance status pretreated resistant/refractory patients.
ER  -