TY  -  JOUR
AU  -  Assandri, Roberto
AU  -  Inzoli, Alessandro
AU  -  Manini, Alessandra
AU  -  Fasoli, Gianluca
AU  -  Martinelli, Pietro
AU  -  Grassini, Angelo
T1  -  Diagnosis of rare entity CD138 negative plasma cell multiple myeloma: the synergy between laboratory and clinician makes the difference
PY  -  2024
Y1  -  2024-05-01
DO  -  10.1701/4262.42403
JO  -  Recenti Progressi in Medicina
JA  -  Recenti Prog Med
VL  -  115
IS  -  5
SP  -  238
EP  -  242
PB  -  Il Pensiero Scientifico Editore
SN  -  2038-1840
Y2  -  2026/04/19
UR  -  http://dx.doi.org/10.1701/4262.42403
N2  -  Summary. Plasma cell multiple myeloma (MM) is a multiform clinical entity characterized by different laboratory hallmarks. This case shows a rare entity of plasma cell myeloma: the entire plasma cell population lack the CD138 expression. In this case, a careful analysis of laboratory finding, particular flow cytometry gating strategies and the use of other ancillary laboratory tests, guide the clinicians to correct diagnosis. The correct evaluation of pre-analytical phase and the correct gating strategy are the necessary conditions to produce robust and solid flow cytometric results. The diagnostic implications of CD138-negative plasma cell are strictly linked to stem cell-like clonogenic features, such as possible more aggressive clinical behaviour and increasing probability of chemotherapy resistance. At this time, clinical laboratory remains the main reference point to MM diagnosis.
ER  -