TY  -  JOUR
AU  -  Fabozzi, Antonio
AU  -  Onorati, Paolo
AU  -  Petroianni, Angelo
AU  -  Steffanina, Alessia
AU  -  Baiocchi, Pia
AU  -  Palange, Paolo
T1  -  Pathophysiological and radiological patterns of pulmonary embolism in cancer vs Covid-19 patients
PY  -  2025
Y1  -  2025-02-01
DO  -  10.1701/4450.44442
JO  -  Recenti Progressi in Medicina
JA  -  Recenti Prog Med
VL  -  116
IS  -  2
SP  -  108
EP  -  117
PB  -  Il Pensiero Scientifico Editore
SN  -  2038-1840
Y2  -  2026/04/16
UR  -  http://dx.doi.org/10.1701/4450.44442
N2  -  Summary. Purpose. Pulmonary embolism (PE) can compromise gases exchanges of patients admitted to respiratory wards. The objectives of this observational study were to identify radiological and arterial blood gases (ABG) differences in PEs documented by computed tomography pulmonary angiogram (CTPA) in Covid-19 pneumonia (C-19) vs cancer patients (CP). Methods. Fifty-one patients diagnosed with PE were evaluated, 18 CP and 33 C-19. Clinical, ABG and radiological parameters were evaluated. Jamovi software was used for statistics. Results. Wells score and D-dimer were both significantly higher in CP compared to C-19 cohort. DVT prevalence was significantly higher in CP patients. Alveolar-arterial O2 gradient (ΔA-aO2) was significantly higher in C-19 compared to CP cohort. PE associated to Covid-19 pneumonia was often bilateral and required a higher need of respiratory supports as High flow nasal cannula (HFNC), Continuous positive airway pressure (CPAP) and Non-invasive ventilation (NIV). In both cohorts, standard PaO2 and standard P/F were significantly lower than PaO2 and P/F. Multivariable linear regression analysis showed that in C-19 cohort PESI score and A-aO2 were independently and positively associated with PE severity. Discussion. These findings show that Wells score and D-dimer may underestimate PE’s risk in C-19 patients. P/F may underestimate the severity of respiratory failure compared to standard P/F. A-aO2 may be a useful tool for prediction of PE severity.
ER  -